Supernova neutrino physics with a nuclear emulsion detector

The existence of the coherent neutrino-nucleus scattering reaction requires to evaluate, for any detector devoted to WIMP searches, the irreducible background due to conventional neutrino sources and at same time, it gives a unique chance to reveal supernova neutrinos. We report here a detailed study concerning a new directional detector, based on the nuclear emulsion technology. A Likelihood Ratio test shows that, in the first years of operations and with a detector mass of several tens of tons, the observation of the supernova signal can be achieved. The determination of the distance of the supernova from the neutrinos and the observation of $^8$B neutrinos are also discussed.Comment: 22 pages, 12 figure

Monitoring Results and Energy Performances Evaluation of Freescoo Solar DEC Systems

This work addresses the energy saving performances of some solar Desiccant and Evaporative Cooling (DEC) systems working with the freescoo technology. The innovative freescoo concept is based on the use two fixed and cooled adsorption beds and advanced indirect evaporative cooling processes. The main feature of this new adsorption bed concept is to allow the simultaneous dehumidification and cooling of air. The systems analyzed have been installed in Italy last here and results based on field monitoring data are here presented. A description of the monitored systems and comparisons between the energy performances based on the main performance indicators such as EER, thermal COP, cooling power, off grid operation data are shown

CASCO: Cosmological and AStrophysical parameters from Cosmological simulations and Observations -- I. Constraining physical processes in local star-forming galaxies

We compare the structural properties and dark matter content of star-forming galaxies taken from the CAMELS cosmological simulations to the observed trends derived from the SPARC sample in the stellar mass range $[10^{9}, 10^{11}]\,\textrm{M}_{\odot}$, to provide constraints on the value of cosmological and astrophysical (SN- and AGN-related) parameters. We consider the size-, internal DM fraction-, internal DM mass- and total-stellar mass relations for all the 1065 simulations from the IllustrisTNG, SIMBA and ASTRID suites of CAMELS, and search for the parameters that minimize the $\chi^{2}$ with respect to the observations. For the IllustrisTNG suite, we find the following constraints for the cosmological parameters: $\Omega_{\textrm{m}} = 0.27_{-0.05}^{+0.01}$, $\sigma_{8} = 0.83_{-0.11}^{+0.08}$ and $S_{8} = 0.78_{-0.09}^{+0.03}$, which are consistent within $1\sigma$ with the results from the nine-year WMAP observations. SN feedback-related astrophysical parameters, which describe the departure of outflow wind energy per unit star formation rate and wind velocity from the reference IllustrisTNG simulations, assume the following values: $A_{\textrm{SN1}} = 0.48_{-0.16}^{+0.25}$ and $A_{\textrm{SN2}} = 1.21_{-0.34}^{+0.03}$, respectively. Therefore, simulations with a lower value of outflow wind energy per unit star formation rate with respect to the reference illustrisTNG simulation better reproduce the observations. Simulations based on SIMBA and ASTRID suites predict central dark matter masses substantially larger than those observed in real galaxies, which can be reconciled with observations only by requiring values of $\Omega_{\textrm{m}}$ inconsistent with cosmological constraints for SIMBA, or simulations characterized by unrealistic galaxy mass distributions for ASTRID.Comment: 24 pages, 10 figures, 9 tables. Accepted by MNRAS for publication; Added a reference to sec. 4.

Long‐term follow‐up comparison of two different bi‐layer dermal substitutes in tissue regeneration: Clinical outcomes and histological findings

Double layer dermal substitute (DS) consist of a 3-dimensional collagen structures and a superficial silicon layer that are positioned within the defect provide to promote tissue regeneration in skin wounds. DS often have unique physical characteristics due to differences in manufacturing techniques. The aim of this study is the clinical and histological comparison of Nevelia and Integra double layer DSs in patients with post-traumatic injury wounds. Thirty patients with post-traumatic wounds localised on the inferior limbs were randomised in 2 groups Nevelia or Integra, followed by autologous dermal epidermal graft (DEG). Clinical results were evaluated through the healing time; Manchester Scar Scale (MSS) and Visual Analog Scale (VAS) at 1, 2, and 3 weeks and after 1 and 3 years. Histological and immunohistochemical evaluation were performed at 0, 2, and 3 weeks. The difference in healing time between groups (P = .467, log-rank test), pain and self-estimation was not statistically significant after 35, 42, and 49 days and at 1-year follow up. Histological data showed evident healing of wound after 2 weeks compared with preoperative with both DSs. At 3 weeks reepithelialisation and dermal regeneration were evident with both substitutes; however Nevelia showed early regenerative properties in terms of epidermal proliferation and dermal renewal compared with Integra. Nevelia showed also a more evident angiogenesis vs Integra evaluated as α-SMA immunohistochemistry. Differences in the MSS score were statistically significant at 3 years follow up in favour of Nevelia group (P = .001). At long-term follow up, Nevelia showed a better clinical outcome measured as MSS score vs Integra measured as MSS. Histological and immunohistochemistry data showed that Nevelia allows faster neoangiogenesis and tissue regeneration with neoformed tissue architecture closer to the physiology of the skin

Towards a decision-support framework for reducing ramp-up effort in plug-and-produce systems

Nowadays, shorter and more flexible production cycles are vital to meet the increasing customized product demand. As any delays and downtimes in the production towards time-to-market means a substantial financial loss, manufacturers take an interest in getting the production system to full utilization as quickly as possible. The concept of plug-and-produce manufacturing systems facilitates an easy integration process through embedded intelligence in the devices. However, a human still needs to validate the functionality of the system and more importantly must ensure that the required quality and performance is delivered. This is done during the ramp-up phase, where the system is assembled and tested first-time. System adaptations and a lack of standard procedures make the ramp-up process still largely dependent on the operator’s experience level. A major problem that currently occurs during ramp-up, is a loss of knowledge and information due to a lack of means to capture the human’s experience. Capturing this information can be used to facilitate future ramp-up cases as additional insights about change actions and their effect on the system could be revealed. Hence, this paper proposes a decision-support framework for plugand-produce assembly systems that will help to reduce the ramp-up effort and ultimately shorten ramp-up time. As an illustrative example, a gluing station developed for the European project openMOS is considered

adipose tissue derived stem cell therapy for post surgical breast reconstruction more light than shadows

Breast cancer remains the most common tumor in women, and new techniques for post- surgical breast reconstruction have been recently introduced. These new procedures include autologous fat grafting with or without the enrichment with autologous stromal vascular fraction (SVF), platelet-derived growth factors and insulin. The reported improvement of fat graft viability with these techniques likely depends on the presence in the SVF of multipotent resident adipose derived-stem cells (ASCs). The clinical advantage derives from the plasticity of ASCs and their ability to generate new functional adipose tissue and vessels. However, there is an ongoing debate regarding the possible interplay between breast tumor cells and resident or transplanted ASCs for their capacity to locally secrete growth factors. Most of the data in the literature concerning ASCs is derived from in vitro models, whereas the knowledge of ASC behavior in vivo remains scarce. Recent reports concerning SVF/ASC enrichment of fat graft did not describe any significant worsening of prognosis for patients undergoing those procedures. However, further studies and longer follow-ups are needed to specifically define technical procedures and to confirm the safety of procedures of SVF/ASC enrichment during post-surgical breast reconstruction

Multiplicity of blaKPC genes and pKpQIL plasmid plasticity in the development of ceftazidime-avibactam and Meropenem coresistance in Klebsiella pneumoniae sequence type 307

In 2021, Klebsiella pneumoniae sequence type 307 (ST307) strains causing pulmonary and bloodstream infections identified in a hospital in Rome, Italy, reached high levels of resistance to ceftazidime-avibactam (CZA). One of these strains reached high levels of resistance to both CZA and carbapenems and carried two copies of bla(KPC-3) and one copy of bla(KPC-31) located on plasmid pKpQIL. The genomes and plasmids of CZA-resistant ST307 strains were analyzed to identify the molecular mechanisms leading to the evolution of resistance and compared with ST307 genomes at local and global levels. A complex pattern of multiple plasmids in rearranged configurations, coresident within the CZA-carbapenem-resistant K. pneumoniae strain, was observed. Characterization of these plasmids revealed recombination and segregation events explaining why K. pneumoniae isolates from the same patient had different antibiotic resistance profiles. This study illustrates the intense genetic plasticity occurring in ST307, one of the most worldwide-diffused K. pneumoniae high-risk clones.In 2021, Klebsiella pneumoniae sequence type 307 (ST307) strains causing pulmonary and bloodstream infections identified in a hospital in Rome, Italy, reached high levels of resistance to ceftazidime-avibactam (CZA). One of these strains reached high levels of resistance to both CZA and carbapenems and carried two copies of bla(KPC-3) and one copy of bla(KPC-31) located on plasmid pKpQIL

Wound Healing: In Vitro and In Vivo Evaluation of a Bio-Functionalized Scaffold Based on Hyaluronic Acid and Platelet-Rich Plasma in Chronic Ulcers

Chronic ulcers are characterized by loss of substance without a normal tendency towards spontaneous healing. The Wound Bed Preparation Guideline advises that after diagnosis, the expert should correct the biological state of the ulcer micro-environment based on TIME principles (Tissue, Infection, Moisture balance, Epidermal). There are many ways to treat such ulcers, for example through use of advanced dressings, negative pressure, surgical toilets, dermal substitutes, autologous skin grafting, and free or local flaps. In vitro and in vivo pre-clinical models hold widely acknowledged potential yet complex limitations. Tissue bioengineering could be an ideal approach to foster innovative strategies in wound healing. Our observational study reports on an in vitro and in vivo evaluation of a bio-functionalized scaffold composed of platelet-rich plasma (PRP) and hyaluronic acid (HA) used in 182 patients affected by chronic ulcers (diabetic and vascular), comparing the results with a control group of 182 patients treated with traditional dressings (HA alone). After 30 days the patients who had undergone the combined treatment (PRP + HA), showed 96.8% +/- 1.5% re-epithelialization, as compared to 78.4% +/- 4.4% in the control group (HA only). Within 80 days, they had 98.4% +/- 1.3% re-epithelialization as compared to 87.8% +/- 4.1% in the control group (HA only; p < 0.05). No local recurrence was observed during the follow-up period. PRP + HA treatment showed stronger regenerative potential in terms of epidermal proliferation and dermal renewal compared with HA alone

Rosa M.a Capel Martínez, José Cepeda Gómez, El Siglo de las Luces : Política y sociedad

Après une séduisante mise au point sur Los siglos XVI-XVII: Cultura y vida cotidiana (due, en 2000, à L. E. Rodríguez-San Pedro et J. L. Sánchez Lora), la collection de synthèses historiques Historia de España 3er milenio, dirigée par Elena Hernández Sandoica, nous offre à présent, sous la plume de deux professeurs de la Complutense, une excellente présentation des enjeux politiques et sociaux du Siglo de las Luces, étude appelée à rendre les plus grands services aux étudiants, voire aux spéc..

Inclusive physical activity games at school: The role of teachers’ attitude toward inclusion

IntroductionInclusive physical activity games at school can be useful for teachers dealing with students with disabilities. The use of inclusive strategies and games can be directly linked to teachers’ self-efficacy and familiarity with the inclusive strategies, while it could be indirectly influenced by their attitude toward inclusion and, in a smaller part, by social desirability in their response. Moreover, teachers’ responses could be different among the different school grades. Therefore, the aim of the current study is to investigate the role of attitude toward inclusion, social desirability, self-efficacy, and familiarity in the use of physical activity games at school in teachers from all school grades.MethodsA sample of 1,583 schoolteachers was asked to fill out a questionnaire about their perceptions of governmental measures, self-efficacy, familiarity with inclusive strategies through physical activity, and two standardized questionnaires assessing attitudes toward inclusion and social desirability.ResultsTeachers from primary school reported lower scores in attitude toward inclusion total score and dimensions, namely impact on teacher, impact on the environment, impact on the other children, and impact on the student with disability. Moreover, the path analysis model showed that the attitude toward inclusion indirectly influenced the use of inclusive strategy and had a small direct effect on familiarity with inclusive strategies and self-efficacy. Social desirability slightly influenced both familiarity and self-efficacy but not the use of inclusive strategies. Familiarity and self-efficacy had a direct effect on the use of inclusive physical activity games.DiscussionThe results of the current study suggest that being familiar with and having a high self-efficacy in implementing inclusive strategies are well related to the use of inclusive strategies at school. In addition, more attention should be given to kindergarten and primary school teachers, who reported lower scores in the attitude toward inclusion and higher scores in social desirability